As demand for biological drugs increases, so does the need for purified protein. Whether for research or to create biotherapeutics, researchers must purify protein following expression and scale-up. The plethora of novel and complex protein-based molecules pose greater challenges for purification professionals, including bispecifics and antibody-drug conjugates. Protein's tendency to aggregate is also a nagging problem, as is working with membrane proteins. The Protein Purification Technologies conference explores the strategies and technologies employed to streamline steps and keep up with industry's growing demands.

CHI's 2nd Annual Protein Purification Technologies conference also examines issues of scale, and innovating 'traditional' technologies such as Protein A and chromatography. Purifying proteins in different expression systems will also be addressed including mammalian, bacterial, and insect cells.

Final Agenda  |  Sponsorship & Exhibits |  Present a Poster  |  View Brochure

Short Courses*

Make the most of your time in Lisbon by adding a short course. Topics include Cancer Immunotherapy, Mutation and Selection Strategies, Designing Antibodies for Function and Low Risk, Transient Protein Expression, Troubleshooting Antibody Constructs, Engineering Bispecific Antibodies, Protein Aggregation, and Protein Purification Strategies.

* separate registration required for short courses

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Agenda-At-A-Glance

PRODUCTIVITY STRATEGIES

KEYNOTE PRESENTATION: Biopharmaceuticals: Past, Present & Future

Frank Riske, Ph.D., Senior Consultant, BioProcess Technology Consultants (BPTC)

Molecular Properties of Antibodies and Their Derivatives Impacting Manufacturing

Stefan Schmidt, Ph.D., MBA, Vice President, Process Science & Production, Rentschler Biotechnology

Sponsored Presentation (Opportunities Available)

ENHANCING PURIFICATION PROCESSES USING HIGH-THROUGHPUT TECHNIQUES

Development of an Automated Parallel System for Production of High-Quality Lead Candidate Antibodies – Keeping Pace with Researchers' Appetites

Lars Linden, Ph.D., Head, Protein Biochemistry, Bayer HealthCare

Enhancing Operational Efficiency during Protein Purification

Martin Bader, Ph.D., Head, Biochemistry, Roche Pharmaceuticals

Recommended Dinner Short Course*: Protein Purification Strategies: Dealing with Proteins that Are Prone to Aggregate

* separate registration required

INCREASING SOLUBILITY AND PURIFYING MEMBRANE PROTEINS

Continuous Aqueous Two-Phase Extraction of Proteins – Novel Process Windows by Increasing Protein Solubility

Christoph Brandenbusch, Ph.D., Group Leader, Department of Biochemical and Chemical Engineering, Laboratory of Thermodynamics, TU Dortmund University

Resolving Perplexing Purification Paradigms with CD-FAST: Calcium Dependent Fragment Assembly Separation Technology

David O'Connell, Ph.D., Lecturer & Director, Biomolecular & Biomedical Science, University College Dublin, and Founder, YourProteome

A Saposin-Based Nanoparticle System for Stabilization of Membrane Proteins

Jens Frauenfeld, Ph.D., CEO, Salipro Biotech AB

AFFINITY PURIFICATION

Versatile Affinity Ligands for Bioseparation Processes

Ana Cecília Afonso Roque, Ph.D., Assistant Professor, Chemistry, UCIBIO, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa

Affitins as a Novel Tailored Class of Robust Reagents for Affinity Chromatography Purification of Antibodies and Non-Immunoglobulin Proteins

Frédéric Pecorari, Ph.D., Researcher, IRS-UN, Cancer Research Center Nantes-Angers, University of Nantes

A Novel IgG-Binding Purification Matrix for Mild Elution

Sophia Hober, Ph.D., Professor, Biotechnology, KTH-Royal Institute of Technology

Problem-Solving Breakout Discussions

IMPROVING AND INNOVATING PURIFICATION PROCESSES

Peptides in Headlock: A Novel Nanobody-Derived Capture/Detection System

Ulrich Rothbauer, Ph.D., Professor, Pharmaceutical Biotechnology, University of Tübingen

Case Study: Human Kinase Crystallization, Phosphatase Co-Expression

Mario Lebendiker, Ph.D., Head, Protein Purification Facilities, Wolfson Centre for Applied Structural Biology, The Hebrew University of Jerusalem

Use of Succinylated Trypsin as a Manufacturing Aid

Nina Madsen, M.S., Scientist, Downstream Process Development, Bristol-Myers Squibb

Development of a Robust Ultrafiltration/Diafiltration Step for Highly Concentrated Drug Substance Using High-Throughput Methods and Aggregation Modelling

Dejan Arzensek, Ph.D., Research Scientist, Downstream Process Development, Sandoz Biopharmaceuticals

A New Shaped Rocking Bioreactor for Insect and Mammalian Cells

Sabine Suppmann, Ph.D., Head, Recombinant Protein Production, Biochemistry Core Facility, Max Planck Institute of Biochemistry

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Event-at-a-Glance

Engineering Stream

- Display of Antibodies

- Engineering Antibodies

- Engineering Bispecifics

- Engineering Next-Generation ADCs

Therapeutics Stream

- Novel Immunotherapy Strategies

- Advancing Bispecifics & Combination Therapy

- Novel Therapies for Cancer & Emerging Targets

Analytical Stream

- Optimisation & Developability

- Analytical Characterisation of Biotherapeutics

- Protein Aggregates & Particles

Expression Stream

- Basic Technologies in a Core Protein Expression Lab

- Optimising Expression Platforms

- Protein Purification Technologies

Why Do Top Researchers Attend PEGS Europe Year After Year?

"The best biologics technology meeting in Europe: a must-attend conference for novel biologics."

- Rakesh D., Ph.D., VP, R&D, MedImmune

"PEGS Europe and PEGS keep going from strength to strength. One week at a PEGS event can stimulate ideas for a whole year. The presentations were exceptional, covering an extraordinary array of antibody and antibody-alternative technologies. PEGS Europe is unparalleled in both scope and quality."

- Kevin R., Ph.D., Scientist, Wellcome Trust Sanger Institute

"Once more, PEGS Europe was an outstanding event with great science and a perfect setting for networking. Very nice combination of topics and speakers."

- Philipp M., Ph.D., Project Leader, Biomedicine, University Hospital of Basel

"PEGS Europe is a gem for protein engineers with depth and breadth in a stimulating and engaging environment! I am glad that I came all the way from California to be a part of it."

- Seung C., Ph.D., Associate Director, Cell Biology, Xencor, Inc.